Epidemiological and clinical boundaries of heart failure with preserved ejection fraction

Eur J Prev Cardiol. 2022 May 27;29(8):1233-1243. doi: 10.1093/eurjpc/zwab077.


Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is associated with relevant morbidity and mortality. However, an evidence-based treatment is still absent. The heterogeneous definitions, differences in aetiology/pathophysiology, and diagnostic challenges of HFpEF made it difficult to define its epidemiological landmarks so far. Several large registries and observational studies have recently disclosed an increasing incidence/prevalence, as well as its prognostic significance. An accurate definition of HFpEF epidemiological boundaries and phenotypes is mandatory to develop novel effective and rational therapeutic approaches.

Keywords: Clinical presentation; Epidemiology; HFpEF; Heart failure; Pathophysiology.

MeSH terms

  • Heart Failure* / diagnosis
  • Heart Failure* / epidemiology
  • Heart Failure* / therapy
  • Humans
  • Prognosis
  • Registries
  • Stroke Volume / physiology
  • Ventricular Function, Left