Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling

Free Radic Biol Med. 2021 Aug 20;172:237-251. doi: 10.1016/j.freeradbiomed.2021.04.034. Epub 2021 Jun 19.


Although myocardial ischemia-reperfusion injury (I/R) and its pathological consequences are the leading cause of morbidity and mortality worldwide, cardioprotective therapeutics are still not on the market. Oxidative stress, a major contributing factor to myocardial I/R, changes transcription of coding and non-coding RNAs, alters post-transcriptional modulations, and regulate protein function. MicroRNA (miRNA) expression can be altered by oxidative stress and microRNAs may also regulate cytoprotective mechanisms and exert cardioprotection againts I/R. Transcriptomic analysis of I/R and oxidative stress-induced alterations followed by microRNA-mRNA target interaction network analysis may reveal microRNAs and their mRNA targets that may play a role in cardioprotection and serve as microRNA therapeutics or novel molecular targets for further drug development. Here we provide a summary of a systematic literature review and in silico molecular network analysis to reveal important cardioprotective microRNAs and their molecular targets that may provide cardioprotection via regulation of redox signalling.

Keywords: Cardioprotection; Ischemia-reperfusion injury; Oxidative-stress; Revers miRNA target prediction; Unbiased bioinformatics; miRNA; microRNA; protectomiR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Humans
  • Infarction
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Myocardial Reperfusion Injury* / genetics
  • Oxidation-Reduction
  • Signal Transduction


  • MicroRNAs