Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma

Front Horm Res. 2021:54:47-57. doi: 10.1159/000515318. Epub 2021 May 7.


Although childhood-onset craniopharyngioma is a low-grade intracranial tumor with excellent prognosis in terms of overall survival, survivors may suffer from devastating consequences caused by hypothalamic damage. Disease- or treatment-related hypothalamic damage leads to disturbed hunger-satiety and thirst feelings, decreased energy expenditure, behavioral problems, disturbances of circadian rhythm, temperature dysregulation, and pituitary dysfunction. These children are at great risk for developing the metabolic syndrome and comorbidities leading to premature mortality. In this chapter, we shall discuss hypothalamic-pituitary morbidity and outcome of childhood-onset craniopharyngioma patients and future perspectives for improvement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Craniopharyngioma* / metabolism
  • Craniopharyngioma* / therapy
  • Humans
  • Hypothalamus
  • Pituitary Diseases*
  • Pituitary Gland
  • Pituitary Neoplasms* / therapy