Enhanced Clostridioides difficile Infection Prevention With a Pharmacy-Controlled Policy That Adds a 3-Strain Lactobacillus Probiotic Concomitantly to Antibiotic Therapy

Clin Infect Dis. 2021 Oct 20;73(8):1524-1527. doi: 10.1093/cid/ciab414.


When 70% of antibiotic users took a 3-strain Lactobacillus probiotic preparation the hospital-wide rate of healthcare-associated Clostridioides difficile infection improved significantly. The incidence of C. difficile infection for those taking the probiotic along with multiple antibiotics or a single high-risk antibiotic was decreased by at least half.

Keywords: Clostridium difficile infection; Lactobacillus; CL1285; Primary prevention; Probiotic.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Clostridioides
  • Clostridioides difficile*
  • Clostridium Infections* / prevention & control
  • Diarrhea
  • Humans
  • Lactobacillus
  • Pharmacy*
  • Policy
  • Probiotics*


  • Anti-Bacterial Agents