Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier

O Semyachkina-Glushkovskaya; D Bragin; O Bragina; Y Yang; A Abdurashitov; A Esmat; A Khorovodov; A Terskov; M Klimova; I Agranovich; I Blokhina; A Shirokov; N Navolokin; V Tuchin; J Kurths

doi:10.1007/978-3-030-48238-1_31

Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier

Adv Exp Med Biol. 2021:1269:197-202. doi: 10.1007/978-3-030-48238-1_31.

Authors

O Semyachkina-Glushkovskaya¹, D Bragin^{2

3}, O Bragina², Y Yang⁴, A Abdurashitov⁵, A Esmat⁵, A Khorovodov⁵, A Terskov⁵, M Klimova⁵, I Agranovich⁵, I Blokhina⁵, A Shirokov⁶, N Navolokin⁷, V Tuchin⁵, J Kurths^{5

8

9}

Affiliations

¹ Saratov State University, Saratov, Russia. glushkovskaya@mail.ru.
² Lovelace Biomedical Research Institute, Albuquerque, NM, USA.
³ University of New Mexico School of Medicine, Departments of Neurology andNeurosurgery, Albuquerque, NM, USA.
⁴ University of New Mexico, College of Pharmacy, Albuquerque, NM, USA.
⁵ Saratov State University, Saratov, Russia.
⁶ Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, Russia.
⁷ Saratov State Medical University, Saratov, Russia.
⁸ Humboldt University, Physics Department, Berlin, Germany.
⁹ Potsdam Institute for Climate Impact Research, Potsdam, Germany.

Abstract

The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.

Keywords: Blood-brain barrier; Cerebral blood oxygen saturation; Loud sound; Mechanisms; Meningeal lymphatic clearance.

MeSH terms

Animals
Biological Transport
Blood-Brain Barrier*
Brain*
Drug Delivery Systems
Rats
Sound

Abstract

MeSH terms

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