Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study

Hypertension. 2021 Jul;78(1):74-81. doi: 10.1161/HYPERTENSIONAHA.121.17073. Epub 2021 May 10.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT03574363.

Keywords: blood pressure; hyperkalemia; hypertension; kidney; mineralocorticoid receptor antagonist.

Publication types

  • Clinical Trial, Phase II
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Double-Blind Method
  • Female
  • Humans
  • Hyperkalemia / chemically induced
  • Hyperkalemia / diagnosis
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care / methods
  • Outcome Assessment, Health Care / statistics & numerical data
  • Piperidines / adverse effects
  • Piperidines / pharmacokinetics
  • Piperidines / therapeutic use*
  • Pyrazoles / adverse effects
  • Pyrazoles / pharmacokinetics
  • Pyrazoles / therapeutic use*
  • Quinolines / adverse effects
  • Quinolines / pharmacokinetics
  • Quinolines / therapeutic use*
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / pathology

Substances

  • KBP-5074
  • Piperidines
  • Pyrazoles
  • Quinolines

Associated data

  • ClinicalTrials.gov/NCT03574363