[Supergenes:Generalists in Gene Expression]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Apr 28;43(2):265-270. doi: 10.3881/j.issn.1000-503X.12419.
[Article in Chinese]


In eukaryote cells,transcription from genome DNA is a key process of gene expression.The transcription products contain not only messenger RNAs that code proteins,but also various types of non-coding RNAs.During transcription,some of the gene loci produce more than one kind of RNA molecule,including coding RNAs and more often non-coding RNAs.These gene loci that generate several kinds of RNA molecules are named supergenes.According to the transcription pattern,supergenes are divided into three types,known as types Ⅰ,Ⅱ and Ⅲ.In this review,we summarize the transcription pattern of each type of supergene,and exposit the role of these genes in cells.

Keywords: gene regulation; non-coding RNA; supergene; transcription.

Publication types

  • Review

MeSH terms

  • Gene Expression
  • RNA, Messenger*


  • RNA, Messenger