DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer

Yi Yu; Jing-Long Wang; Li-Li Meng; Chun-Ting Hu; Zhao-Wen Yan; Zhi-Ping He; Xiao-Qin Shi; Guo-Hui Fu; Li-Dong Zu

doi:10.3389/fonc.2021.650360

DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer

Front Oncol. 2021 Apr 21:11:650360. doi: 10.3389/fonc.2021.650360. eCollection 2021.

Authors

Yi Yu¹, Jing-Long Wang², Li-Li Meng², Chun-Ting Hu², Zhao-Wen Yan², Zhi-Ping He², Xiao-Qin Shi¹, Guo-Hui Fu^{1

2}, Li-Dong Zu²

Affiliations

¹ Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
² Department of Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Colorectal cancer (CRC) is one of the most malignant cancers, and its incidence is still steadily increasing. The DDX RNA helicase family members have been found to play a role in various cancers; however, the role of DDX54 in colorectal cancer is still unclear and needed to be defined. Here, we found DDX54 was overexpressed in CRC tissues by the label-free mass spectrum, which was also verified in tissue microarray of colon cancer, as well as the CRC cell lines and TCGA database. High DDX54 level was correlated with tumor stage and distant metastasis, which always indicated a poor prognosis to the CRC patients. DDX54 could promote the proliferation and mobility of CRC cells through increasing the phosphorylation level p65 and AKT leading to the tumorigenesis. Here, we have preliminarily studied the function of DDX54 in CRC, which would improve our understanding of the underlying biology of CRC and provide the new insight that could be translated into novel therapeutic approaches.

Keywords: AKT; DDX54; colorectal cancer; p65; proteomics.