Ethopropazine and benztropine in neuroleptic-induced parkinsonism

J Clin Psychiatry. 1979 Mar;40(3):147-52.


In a 12-week controlled study ethopropazine was compared to benztropine in the treatment of parkinsonism induced by fluphenazine enanthate in 60 schizophrenic outpatients. Ethopropazine and benztropine were found to be equally effective in controlling parkinsonian symptoms and were as efficacious as procyclidine, their previous antiparkinsonian drug. However, benztropine treated patients had a significant increase in tardive dyskinesia compared to their condition during procyclindine treatment, and significantly more anxiety and depression than ethopropazine treated patients. This suggests that benztropine is not the anticholinergic drug of choice in the treatment of neuroleptic-induced parkinsonian symptoms, because of its more toxic central and peripheral atropinic effect.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Benztropine / adverse effects
  • Benztropine / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Dyskinesia, Drug-Induced / drug therapy
  • Female
  • Fluphenazine / adverse effects*
  • Fluphenazine / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease, Secondary / chemically induced*
  • Parkinson Disease, Secondary / drug therapy
  • Phenothiazines / adverse effects
  • Phenothiazines / therapeutic use*
  • Procyclidine / therapeutic use
  • Schizophrenia / drug therapy
  • Tropanes / therapeutic use*


  • Phenothiazines
  • Tropanes
  • Benztropine
  • Procyclidine
  • Fluphenazine