Ann Intern Med. 2021 May;174(5):ITC65-ITC80. doi: 10.7326/AITC202105180. Epub 2021 May 11.


Most psychiatric care is delivered in primary care settings, where depression is the most common presenting psychiatric symptom. Given the high prevalence of depression worldwide and the well-established consequences of untreated depression, the ability of primary care clinicians to effectively diagnose and treat it is critically important. This article offers up-to-date guidance for the diagnosis and treatment of major depressive disorder, including practical considerations for delivering optimal and efficient care for these patients.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / therapeutic use
  • Depression / diagnosis*
  • Depression / therapy*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / therapy
  • Diagnosis, Differential
  • Humans
  • Mass Screening / methods*
  • Primary Health Care*
  • Psychiatric Status Rating Scales
  • Risk Factors


  • Antidepressive Agents