Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease

Gut. 2022 Apr;71(4):842-844. doi: 10.1136/gutjnl-2021-324727. Epub 2021 May 10.

Authors

Affiliations

¹ Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University, Heidelberg, Germany.
² Department of Medicine, Krankenhaus Salem, Heidelberg, Baden-Württemberg, Germany.
³ Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Baden-Württemberg, Germany.
⁴ Krankenhaus Salem, Heidelberg, Baden-Württemberg, Germany helmut_karl.seitz@urz.uni-heidelberg.de.

^# Contributed equally.

PMID: 33972357
DOI: 10.1136/gutjnl-2021-324727

No abstract available

Keywords: alcohol; alcoholic liver disease; clinical trials; cytochrome p450.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chlormethiazole
Cytochrome P-450 CYP2E1*
Ethanol
Humans
Liver Diseases, Alcoholic* / drug therapy

Substances

Chlormethiazole
Ethanol
Cytochrome P-450 CYP2E1