Use of 24-F-1,25-dihydroxyvitamin D3 to prevent parturient paresis in dairy cows

J Dairy Sci. 1988 May;71(5):1211-9. doi: 10.3168/jds.S0022-0302(88)79676-9.

Abstract

Forty-one aged Jersey cows were fed a high Ca diet prior to parturition to predispose them to parturient paresis. Twenty-one of the cows were treated with 24-F-1,25-dihydroxyvitamin D3, a synthetic analogue of 1,25-dihydroxyvitamin D3, 7 d before the expected parturition. Treated cows received either 100 micrograms (n = 7) or 150 micrograms (n = 14) of 24-F-1,25-dihydroxyvitamin D3, intramuscularly at 7-d intervals until the cow calved. Incidence of parturient paresis among untreated animals was 85% (17/20). Injections of 100 micrograms of 24-F-1,25-dihydroxyvitamin D3 reduced the incidence of parturient paresis to 43% (3/7), whereas 150 micrograms injections of 24-F-1,25-dihydroxyvitamin D3 reduced the incidence of parturient paresis to 29% (4/14). Plasma concentrations of hydroxyproline were not elevated prior to parturition in 24-F-1,25-dihydroxyvitamin D3-treated cows, indicating that treatment did not stimulate bone resorption and that the ability of 24-F-1,25-dihydroxyvitamin D3 to prevent parturient paresis likely resides in its ability to stimulate intestinal Ca absorption prior to parturition. Further, cows treated with 24-F-1,25-dihydroxyvitamin D3 that developed parturient paresis had lower than normal plasma concentrations of 1,25-dihydroxyvitamin D, indicating that 24-F-1,25-dihydroxyvitamin D3 treatment impairs the metabolism of 25-hydroxyvitamin D in response to hypocalcemia. These data suggest that injection of 24-F-1,25-dihydroxyvitamin D3, delivered at 7-d intervals prior to parturition, can effectively reduce incidence of parturient paresis in dairy cows.

MeSH terms

  • Animals
  • Calcitriol / administration & dosage
  • Calcitriol / analogs & derivatives*
  • Calcitriol / blood
  • Calcitriol / therapeutic use
  • Calcium / blood*
  • Cattle
  • Cattle Diseases / blood
  • Cattle Diseases / prevention & control*
  • Creatinine / blood
  • Female
  • Hydroxyproline / blood
  • Injections, Intramuscular
  • Parathyroid Hormone / blood
  • Parturient Paresis / blood
  • Parturient Paresis / prevention & control*
  • Pregnancy

Substances

  • Parathyroid Hormone
  • 24-fluoro-1,25-dihydroxycholecalciferol
  • Creatinine
  • Calcitriol
  • Hydroxyproline
  • Calcium