A unified resource and configurable model of the synapse proteome and its role in disease

Sci Rep. 2021 May 11;11(1):9967. doi: 10.1038/s41598-021-88945-7.

Abstract

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein-protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Genetic
  • Humans
  • Neurons / metabolism
  • Neurons / physiology
  • Protein Interaction Mapping / methods
  • Proteome / metabolism
  • Proteomics
  • Synapses / genetics*
  • Synapses / metabolism*
  • Synapses / physiology*

Substances

  • Proteome