Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome

J Pediatr. 1988 Aug;113(2):393-400. doi: 10.1016/s0022-3476(88)80290-7.


Seventy girls with Turner syndrome, 4 to 12 years of age, participated in a prospective, randomized study to determine the effects on growth of methionyl human growth hormone (met-hGH) or oxandrolone. Subjects were randomly assigned to receive either no treatment (control) or met-hGH (0.125 mg/kg three times per week), oxandrolone (0.125 mg/kg/day), or combination met-hGH plus oxandrolone. At the end of an initial period of 12 to 20 months, patients in the original control and oxandrolone groups were given combination met-hGH plus oxandrolone. At that time the dosage of oxandrolone was lowered to 0.0625 mg/kg/day. Sixty-five subjects have now completed the first 3 years of the study. Compared with the control growth rate for year 1 (3.8 cm/yr), significant increases in growth rate were seen in all 3 years of combination therapy (9.8, 7.4, and 6.1 cm/yr, respectively) and in the first 2 years of treatment with met-hGH alone (6.6, 5.4, and 4.6 cm/yr). When growth velocity was expressed as standard deviation for age in girls with Turner syndrome, significant increases relative to the control group for year 1 (-0.1 SD) were seen in all three years of both combination therapy and met-hGH alone (combination, +6.6, +4.3, +3.0 SD; met-hGH, +3.1, +2.0, +1.4 SD). After 3 years of treatment, predicted adult height by the method of Bayley-Pinneau increased 4.5 cm in the met-hGH group and 8.2 cm in the combination group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Body Height
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Growth / drug effects
  • Growth Hormone / administration & dosage
  • Growth Hormone / analogs & derivatives*
  • Growth Hormone / therapeutic use
  • Hormones / administration & dosage
  • Hormones / therapeutic use*
  • Human Growth Hormone
  • Humans
  • Oxandrolone / administration & dosage
  • Oxandrolone / therapeutic use*
  • Prospective Studies
  • Random Allocation
  • Turner Syndrome / drug therapy*


  • Hormones
  • Human Growth Hormone
  • Oxandrolone
  • Growth Hormone