Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling

Environ Toxicol. 2021 Aug;36(8):1664-1673. doi: 10.1002/tox.23162. Epub 2021 May 12.


Lead (Pb) poses a potential environmental risk factor for cognitive dysfunction during early life and childhood. Resveratrol is considered a promising antioxidant with respect to the prevention of cognitive deficits and act as a potent SIRT1 agonist. Herein, this study aims to investigate the profile of neurogenesis markers following Pb exposure and to determine the regulatory role of resveratrol in this process. We confirmed firstly the protective effects of resveratrol against Pb-induced impairments of hippocampal neurogenesis in Male SD rats. Pb exposure early in life caused the altered expression of Ki-67, NeuN, caspase-3 and SIRT1 signaling, thereby resulting in spatial cognitive impairment of adolescent rats. As expected, resveratrol reduced cognitive damage and promoted neurogenesis in Pb-induced injury by regulation of SIRT1 pathway. Collectively, our study establishes the efficacy of resveratrol as a neuroprotective agent and provides a strong rationale for further studies on SIRT1-mediated mechanisms of neuroprotective functions.

Keywords: SIRT1; lead; learning and memory; neurogenesis; resveratrol.

MeSH terms

  • Animals
  • Hippocampus / metabolism
  • Lead
  • Male
  • Neurogenesis
  • Rats
  • Rats, Sprague-Dawley
  • Resveratrol
  • Sirtuin 1* / metabolism
  • Stilbenes*


  • Stilbenes
  • Lead
  • Sirt1 protein, rat
  • Sirtuin 1
  • Resveratrol