Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Open Forum Infect Dis. 2021 Apr 16;8(5):ofab077. doi: 10.1093/ofid/ofab077. eCollection 2021 May.


Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.

Keywords: HIV; bictegravir; diabetes; hyperglycemia; integrase strand transfer inhibitors.