An NTD supersite of attack

Cell Host Microbe. 2021 May 12;29(5):744-746. doi: 10.1016/j.chom.2021.04.010.


To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal
  • COVID-19*
  • Humans
  • Protein Binding
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus*


  • Antibodies, Monoclonal
  • Spike Glycoprotein, Coronavirus