An NTD supersite of attack

Shee-Mei Lok

doi:10.1016/j.chom.2021.04.010

An NTD supersite of attack

Cell Host Microbe. 2021 May 12;29(5):744-746. doi: 10.1016/j.chom.2021.04.010.

Author

Shee-Mei Lok¹

Affiliation

¹ Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.

Abstract

To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite.

Publication types

Comment

MeSH terms

Antibodies, Monoclonal
COVID-19*
Humans
Protein Binding
SARS-CoV-2
Spike Glycoprotein, Coronavirus*

Substances

Antibodies, Monoclonal
Spike Glycoprotein, Coronavirus