Rare EBV-associated B cell neoplasms of the gastrointestinal tract

Ashley K Volaric; Kunwar Singh; Alejandro A Gru

doi:10.1053/j.semdp.2021.04.004

Rare EBV-associated B cell neoplasms of the gastrointestinal tract

Semin Diagn Pathol. 2021 Jul;38(4):38-45. doi: 10.1053/j.semdp.2021.04.004. Epub 2021 Apr 29.

Authors

Ashley K Volaric¹, Kunwar Singh¹, Alejandro A Gru²

Affiliations

¹ Department of Pathology, Stanford Medicine, Stanford, CA, United States.
² Department of Pathology, University of Virginia, Charlottesville, VA, United States. Electronic address: AAG4B@hscmail.mcc.virginia.edu.

PMID: 33985830
DOI: 10.1053/j.semdp.2021.04.004

Abstract

EBV-driven B cell neoplasms can rarely present as an extranodal mass in the gastrointestinal tract and can be missed, even by experienced pathologists, because of this uncommon presentation. A selection of these neoplasms, namely EBV-positive diffuse large B cell lymphoma, not otherwise specified (DLBCL NOS), EBV-positive mucocutaneous ulcer (EBV MCU), extracavitary primary effusion lymphoma (EPEL), and EBV-positive Burkitt lymphoma, will be discussed in the present review. Besides the common thread of EBV positivity, these lymphoproliferative disorders arise in unique clinical settings that are often associated with immunodeficiency, immunosuppression or immunosenescence and can present as solitary masses albeit rarely, within the gastrointestinal tract.

Keywords: EBV; GI tract; HHV-8; Lymphoma.

Publication types

Case Reports
Review

MeSH terms

B-Lymphocytes
Epstein-Barr Virus Infections*
Gastrointestinal Tract
Herpesvirus 4, Human
Humans
Lymphoma, Large B-Cell, Diffuse*
Lymphoproliferative Disorders*