New lymphatic cell formation is associated with damaged brain tissue clearance after penetrating traumatic brain injury

Sci Rep. 2021 May 13;11(1):10193. doi: 10.1038/s41598-021-89616-3.

Abstract

We characterized the tissue repair response after penetrating traumatic brain injury (pTBI) in this study. Seventy specific pathogen-free Kunming mice were randomly divided into the following groups: normal control, 1, 3, 7, 15, 21, and 30 days after pTBI. Hematoxylin and eosin (H&E) staining, immunohistochemistry, and immunofluorescence were performed to examine and monitor brain tissue morphology, and the distribution and expression of lymphatic-specific markers lymphatic vessel endothelial receptor-1 (LYVE-1), hematopoietic precursor cluster of differentiation 34 (CD34) antigen, and Prospero-related homeobox-1 (PROX1) protein. H&E staining revealed that damaged and necrotic tissues observed on day 1 at and around the injury site disappeared on day 7, and there was gradual shrinkage and disappearance of the lesion on day 30, suggesting a clearance mechanism. We explored the possibility of lymphangiogenesis causing this clearance as part of the post-injury response. Notably, expression of lymphangiogenesis markers LYVE-1, CD34, and PROX1 was detected in damaged mouse brain tissue but not in normal tissue. Moreover, new lymphatic cells and colocalization of LYVE-1/CD34 and LYVE-1/PROX1 were also observed. Our findings of the formation of new lymphatic cells following pTBI provide preliminary insights into a post-injury clearance mechanism in the brain. Although we showed that lymphatic cells are implicated in brain tissue repair, further research is required to clarify the origin of these cells.

MeSH terms

  • Animals
  • Antigens, CD34 / analysis
  • Antigens, CD34 / immunology
  • Antigens, CD34 / metabolism
  • Biomarkers / metabolism
  • Brain / immunology
  • Brain / metabolism*
  • Brain / pathology*
  • Brain Injuries, Traumatic / immunology
  • Cell Differentiation
  • China
  • Endothelium, Vascular / metabolism
  • Female
  • Head Injuries, Penetrating / immunology*
  • Homeodomain Proteins / analysis
  • Homeodomain Proteins / metabolism
  • Immunohistochemistry
  • Lymphangiogenesis / physiology
  • Lymphatic Vessels / pathology
  • Male
  • Membrane Transport Proteins / analysis
  • Membrane Transport Proteins / metabolism
  • Mice
  • Necrosis
  • Tumor Suppressor Proteins / analysis
  • Tumor Suppressor Proteins / metabolism

Substances

  • Antigens, CD34
  • Biomarkers
  • Homeodomain Proteins
  • Membrane Transport Proteins
  • Tumor Suppressor Proteins
  • Xlkd1 protein, mouse
  • prospero-related homeobox 1 protein