Influence of daily aspirin therapy on ACE2 expression and function-implications for SARS-CoV-2 and patients with aspirin-exacerbated respiratory disease

Clin Exp Allergy. 2021 Jul;51(7):968-971. doi: 10.1111/cea.13898. Epub 2021 May 26.

Authors

Kathleen M Buchheit¹, Jonathan J Hacker², Deborah H Gakpo², Jyotsna Mullur², Aaqib Sohail¹, Tanya M Laidlaw¹

Affiliations

¹ Department of Medicine, The Division of Allergy and Clinical Immunology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
² Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA.

No abstract available

Keywords: ACE2; Aspirin; COVID-19; NSAID; SARS-CoV-2; TMPRSS2; aspirin-exacerbated respiratory disease; asthma.

Publication types

Letter
Research Support, N.I.H., Intramural

MeSH terms

Adult
Angiotensin-Converting Enzyme 2 / biosynthesis*
Aspirin* / administration & dosage
Aspirin* / adverse effects
COVID-19 Drug Treatment*
COVID-19* / enzymology
COVID-19* / pathology
Female
Gene Expression Regulation, Enzymologic / drug effects*
Humans
Male
Middle Aged
SARS-CoV-2 / metabolism*

Substances

ACE2 protein, human
Angiotensin-Converting Enzyme 2
Aspirin

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