Efficacy of topical application of autologous platelet-rich plasma in adult tonsillectomy patients: a randomised control study

J Laryngol Otol. 2021 Jun;135(6):539-544. doi: 10.1017/S0022215121000402. Epub 2021 May 14.

Abstract

Objective: Tonsillectomy is a painful surgery performed in cases of recurrent tonsillitis. Application of platelet-rich plasma to diminish the pain and morbidity post-tonsillectomy is gaining importance. This study evaluated post-operative pain and morbidity after autologous platelet-rich plasma application on the tonsil beds during tonsillectomy.

Method: Participants were randomised into group 1 (n = 28, peri-operative platelet-rich plasma intervention) and group 2 (n = 28, control). Post-tonsillectomy, patients were assessed (day 0, 1, 2, 3, 7 and 14) for pain, healing and time taken to return to normal activity. Data were analysed by independent t-test and chi-square test with p ≤ 0.05 as the significance level.

Results: A significant decrease in the mean pain score up to day 7 (p < 0.05) and tonsillar fossae healing on days 2 and 3 (p < 0.05) post-tonsillectomy was noted. The majority of the patients returned to their routine activities after a week post-tonsillectomy.

Conclusion: Platelet-rich plasma application was effective in accentuating healing and reducing post-tonsillectomy pain and morbidity.

Keywords: Pain; Palatine Tonsil; Platelet-Rich Plasma; Tonsillectomy; Visual Analog Scale.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain, Postoperative / therapy*
  • Platelet-Rich Plasma*
  • Postoperative Care*
  • Postoperative Complications / prevention & control*
  • Single-Blind Method
  • Tonsillectomy*
  • Tonsillitis / surgery*
  • Young Adult