Evaluating the Presence of Replication-Competent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From Nursing Home Residents With Persistently Positive Reverse Transcription Polymerase Chain Reaction (RT-PCR) Results

Clin Infect Dis. 2022 Feb 11;74(3):525-528. doi: 10.1093/cid/ciab436.


Replication-competent virus has not been detected in individuals with mild to moderate coronavirus disease 2019 (COVID-19) more than 10 days after symptom onset. It is unknown whether these findings apply to nursing home residents. Of 273 specimens collected from nursing home residents >10 days from the initial positive test, none were culture positive.

Keywords: COVID-19; RT-PCR; SARS-CoV-2; nursing home; viral culture.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • COVID-19*
  • Humans
  • Nursing Homes
  • Reverse Transcriptase Polymerase Chain Reaction
  • Reverse Transcription
  • SARS-CoV-2*

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