Impact of COVID-19 vaccination program on seroprevalence in blood donors in England, 2021

J Infect. 2021 Aug;83(2):237-279. doi: 10.1016/j.jinf.2021.04.037. Epub 2021 May 11.


The COVID-19 vaccination programme commenced in England on 8th December 2020 primarily based on age; by 7th March 2021 approximately 93% of the English population aged 70+ years had received at least 1 dose of either the Pfizer BioNTech or AstraZeneca vaccines. Using a nucleoprotein assay that detects antibodies following natural infection only and a spike assay that detects infection and vaccine-induced responses, we aim to describe the impact of vaccination on SARS-CoV-2 antibody prevalence in English blood donors.

Keywords: Antibodies; Blood Donors; COVID-19; COVID-19 Serological Testing; COVID-19 vaccines; SARS-CoV-2; Surveys.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aged
  • Antibody Formation
  • Blood Donors
  • COVID-19 Vaccines*
  • COVID-19*
  • England / epidemiology
  • Health Personnel
  • Humans
  • RNA, Messenger
  • SARS-CoV-2
  • Seroepidemiologic Studies
  • Vaccination


  • COVID-19 Vaccines
  • RNA, Messenger