Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex

Neurosci Res. 1988 Jun;5(5):465-73. doi: 10.1016/0168-0102(88)90030-2.


The influence of dopamine and its antagonists on neuronal activity related to the delay period of a delayed response task was examined in the monkey prefrontal cortex. Iontophoretically applied dopamine enhanced the delay-related neuronal activity, while fluphenazine and haloperidol attenuated the activity. Sulpiride had no effect on the activity. The results suggest that dopamine promotes processing of spatial short-term memory by increasing memory-related activity in the primate prefrontal cortex, probably via D1-type dopamine receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / physiology
  • Conditioning, Operant
  • Dopamine / pharmacology*
  • Macaca
  • Memory, Short-Term / drug effects*
  • Neurons / drug effects*


  • Dopamine