The association of genetically determined serum glycine with cardiovascular risk in East Asians

Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1840-1844. doi: 10.1016/j.numecd.2021.03.010. Epub 2021 Apr 7.


Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.

Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).

Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD.

Keywords: Cardiovascular risk; Circulating glycine concentration; Genetic association; Genome-wide association study.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Biomarkers / blood
  • Carbamoyl-Phosphate Synthase (Ammonia) / genetics*
  • Case-Control Studies
  • China / ethnology
  • Coronary Angiography
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / ethnology
  • Coronary Artery Disease / genetics*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Glycine / blood*
  • Heart Disease Risk Factors
  • Humans
  • Incidence
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Prospective Studies
  • Risk Assessment
  • Singapore / epidemiology


  • Biomarkers
  • CPS1 protein, human
  • Carbamoyl-Phosphate Synthase (Ammonia)
  • Glycine