Dataset for the reporting of carcinoma of the esophagus in resection specimens: recommendations from the International Collaboration on Cancer Reporting

Hum Pathol. 2021 Aug:114:54-65. doi: 10.1016/j.humpath.2021.05.003. Epub 2021 May 13.


Background and objectives: A standardized data set for esophageal carcinoma pathology reporting was developed based on the approach of the International Collaboration on Cancer Reporting (ICCR) for the purpose of improving cancer patient outcomes and international benchmarking in cancer management.

Materials and methods: The ICCR convened a multidisciplinary international expert panel to identify the best evidence-based clinical and pathological parameters for inclusion in the data set for esophageal carcinoma. The data set incorporated the current edition of the World Health Organization Classification of Tumours of the Digestive System, and Tumour-Node-Metastasis staging systems.

Results: The scope of the data set encompassed resection specimens of the esophagus and esophagogastric junction with tumor epicenter ≤20 mm into the proximal stomach. Core reporting elements included information on neoadjuvant therapy, operative procedure used, tumor focality, tumor site, tumor dimensions, distance of tumor to resection margins, histological tumor type, presence and type of dysplasia, tumor grade, extent of invasion in the esophagus, lymphovascular invasion, response to neoadjuvant therapy, status of resection margin, ancillary studies, lymph node status, distant metastases, and pathological staging. Additional non-core elements considered useful to report included clinical information, specimen dimensions, macroscopic appearance of tumor, and coexistent pathology.

Conclusions: This is the first international peer-reviewed structured reporting data set for surgically resected specimens of the esophagus. The ICCR carcinoma of the esophagus data set is recommended for routine use globally and is a valuable tool to support standardized reporting, to benefit patient care by providing diagnostic and prognostic best-practice parameters.

Keywords: Carcinoma; Data set; Esophagus; International Collaboration onCancer Reporting; Pathology; Structured report.

MeSH terms

  • Benchmarking / standards
  • Carcinoma / secondary
  • Carcinoma / surgery*
  • Chemoradiotherapy, Adjuvant
  • Cooperative Behavior
  • Data Accuracy
  • Datasets as Topic / standards*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / surgery*
  • Esophagectomy*
  • Esophagogastric Junction / pathology
  • Esophagogastric Junction / surgery*
  • Evidence-Based Medicine / standards
  • Humans
  • International Cooperation
  • Neoadjuvant Therapy
  • Neoplasm Grading
  • Neoplasm Staging
  • Research Design / standards*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery*
  • Treatment Outcome