Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

David H Canaday; Lenore Carias; Oladayo A Oyebanji; Debbie Keresztesy; Dennis Wilk; Michael Payne; Htin Aung; Kerri St Denis; Evan C Lam; Christopher F Rowley; Sarah D Berry; Cheryl M Cameron; Mark J Cameron; Brigid Wilson; Alejandro B Balazs; Stefan Gravenstein; Christopher L King

doi:10.1093/cid/ciab447

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

Clin Infect Dis. 2021 Dec 6;73(11):2112-2115. doi: 10.1093/cid/ciab447.

Authors

David H Canaday^{1

2}, Lenore Carias¹, Oladayo A Oyebanji¹, Debbie Keresztesy¹, Dennis Wilk¹, Michael Payne¹, Htin Aung¹, Kerri St Denis³, Evan C Lam³, Christopher F Rowley⁴, Sarah D Berry⁵, Cheryl M Cameron¹, Mark J Cameron¹, Brigid Wilson², Alejandro B Balazs³, Stefan Gravenstein^{6

7}, Christopher L King^{1

8}

Affiliations

¹ Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
² Geriatric Research, Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
³ Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA.
⁴ Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁵ Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
⁶ Division of Geriatrics and Palliative Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁷ Center on Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA.
⁸ Division of Infectious Diseases, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.

Abstract

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

Keywords: COVID-19; SARS-CoV-2; geriatrics; vaccine.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

BNT162 Vaccine
COVID-19 Vaccines
COVID-19*
Humans
Nursing Homes
RNA, Messenger
SARS-CoV-2*
Vaccines, Synthetic
mRNA Vaccines

Substances

COVID-19 Vaccines
RNA, Messenger
Vaccines, Synthetic
BNT162 Vaccine

Abstract

Publication types

MeSH terms

Substances

Grants and funding