Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1- c][1,2,4]Triazin-4-ols

Chem Heterocycl Compd (N Y). 2021;57(4):473-478. doi: 10.1007/s10593-021-02926-2. Epub 2021 May 12.


An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Supplementary information: The online version contains supplementary material available at 10.1007/s10593-021-02926-2.

Keywords: 3-nitroazolo[5,1-с][1,2,4]triazines; Coxsackie B3 virus; antiviral activity; influenza virus; triazines; α-nitro ketones.