Prenatal diagnosis of a de novo unbalanced translocation (4p+) following in vitro fertilization

Prenat Diagn. 1988 May;8(4):297-301. doi: 10.1002/pd.1970080409.


We report herein a de novo unbalanced chromosome translocation in a fetus resulting from in vitro fertilization technology. Prenatal diagnostic analysis of an amniotic fluid revealed a 46,XX,4p+ karyotype. The origin of the extra material on the short arm of chromosome 4 could not be identified by a variety of banding techniques. However, examination of fetal parts did reveal some dysmorphic features.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Chromosome Aberrations / diagnosis*
  • Chromosome Aberrations / etiology
  • Chromosome Disorders
  • Chromosomes, Human, Pair 4*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Karyotyping
  • Pregnancy
  • Prenatal Diagnosis*
  • Translocation, Genetic*