Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

Xian-Bin Zhou; Shi-Wen Xu; Li-Ping Ye; Xin-Li Mao; Ya-Hong Chen; Jian-Fen Wu; Yue Cai; Yi Wang; Li Wang; Shao-Wei Li

doi:10.1016/j.reth.2021.01.003

Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

Regen Ther. 2021 Feb 3:17:51-60. doi: 10.1016/j.reth.2021.01.003. eCollection 2021 Jun.

Authors

Xian-Bin Zhou¹, Shi-Wen Xu², Li-Ping Ye¹, Xin-Li Mao¹, Ya-Hong Chen³, Jian-Fen Wu¹, Yue Cai¹, Yi Wang¹, Li Wang⁴, Shao-Wei Li¹

Affiliations

¹ Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, LinHai, Zhejiang, China.
² Wenzhou Medical University, Wenzhou, Zhejiang, China.
³ Health Management Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
⁴ College of Basic Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Abstract

Endoscopic submucosal dissection (ESD) has been widely accepted as an effective treatment for early esophageal cancer. However, post-ESD esophageal stricture remains a thorny issue. We herein review many strategies for preventing post-ESD esophageal stricture, as well as discuss their strengths and weaknesses. These strategies include pharmacological prophylaxis, esophageal stent and tissue engineering and regenerative medicine treatment. In this review, we summarize these studies and discuss the underlying progress and future directions of tissue engineering and regenerative medicine treatment.

Keywords: 5-FU, 5-Fluorouracil; ADSC, Autologous adipose-derived stem cells; ASGS, autologous skin graft surgery; ChST15, carbohydrate sulfotransferase 15; EBD, endoscopic balloon dilation; ECM, extracellular matrix; ESD, endoscopic submucosal dissection; Endoscopic submucosal dissection; Esophageal stricture; FCMS, fully covered metal stent; OMECs, oral mucosal epithelial cell sheets; PGAs, polyglycolic acid sheet; PIPAAm, poly(N-isopropylacrylamide); Regenerative medicine; SESCNs, superficial esophageal squamous cell neoplasms; SIS, small intestinal submucosa; SeMS, self-expandable metal stents; TA, triamcinolone acetonide; TS-PGA, triamcinolone-soaked polyglycolic acid sheet; Tissue engineering; Tβ4, Thymosin β4; ccESTD, complete circular endoscopic submucosal tunnel dissection; siRNA, small interfering RNA.