Regional assignment of human tissue factor gene (F3) to chromosome 1p21-p22

Somat Cell Mol Genet. 1988 Jul;14(4):407-10. doi: 10.1007/BF01534649.


Tissue factor, or coagulation factor III, is a membrane-bound glycoprotein and acts as a cofactor for factor VII-dependent initiation of blood coagulation. The tissue factor gene (F3) was previously assigned to human chromosome 1, region p21-pter. The present report has further refined the mapping position to 1p21-p22 using a cDNA probe for the tissue factor gene and in situ hybridization to metaphase chromosomes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Humans
  • Nucleic Acid Hybridization
  • Thromboplastin / genetics*


  • Thromboplastin