Background: Fenoldopam, a vasodilating agent, may represent a potential therapeutic opportunity to increase renal perfusion in those conditions where renal hemodynamics are severely impaired by vascular sub-occlusion, as, indeed, is the case in thrombotic microangiopathies.
Methods: The renal resistance index (RRI) was measured, on and off fenoldopam, in 27 children with STEC-HUS.
Results: A 12% decrease in RRI was observed on fenoldopam compared to off treatment without changes in the systemic hemodynamics and with no side effects.
Conclusions: If confirmed in larger series, fenoldopam may become an important addition to supportive care to reduce ischemic damage in STEC-HUS and improve long-term outcomes.
Keywords: Children; Fenoldopam; Hemolytic uremic syndrome; Renal hemodynamics; Renal resistance index; Thrombotic microangiopathy.
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