Survival Rates of Dental Implants in Patients with Papillon-Lefévre Syndrome: A Systematic Review

J Contemp Dent Pract. 2021 Jan 1;22(1):93-100.


Aim: The present review aimed to summarize and evaluate the available literature regarding the survival rate and outcomes of dental implants in patients with Papillon-Lefèvre syndrome (PLS).

Materials and methods: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all data published from January 1996 till April 2020 using a combination of the following keywords: 'Papillon Lefévre Syndrome', 'prosthodontic rehabilitation' and 'dental implant' according to the PRISMA guidelines for the focused research question constructed using the PICO criteria. Clinical trials and observational studies on implant placement in PLS patients reported in English language were included in the study.

Results: A total of 10 studies (nine case reports and one case series) comprising 124 dental implants placed in 13 PLS patients were included. The follow-up period ranged from 4 months to 9 years. With regard to implant loading, 9 studies reported delayed loading, while one study did not provide any information regarding the nature of implant loading. The design of prosthodontic superstructure was either a removable or fixed prosthesis. Out of the 124 inserted implants, 20 (16%) were reported as failed. The overall survival rate was 84%.

Conclusion: The limited available evidence suggests that the survival rate of dental implants in patients with PLS is lower than that among healthy individuals. Nevertheless, no strict contraindication for implant-supported prosthesis seems to be justified in this group of patients. Further longitudinal studies with adequate follow-up periods are highly warranted.

Clinical significance: The prognosis of implant treatment for PLS patients has not yet been established. Dental practitioners should follow a careful approach in planning the dental implant treatment for this cohort of patients.

Keywords: Dental implants; Papillon-Lefévre syndrome; Prosthodontic rehabilitation Survival rate..

Publication types

  • Systematic Review

MeSH terms

  • Dental Implantation, Endosseous
  • Dental Implants*
  • Dental Prosthesis, Implant-Supported
  • Dental Restoration Failure
  • Dentists
  • Follow-Up Studies
  • Humans
  • Papillon-Lefevre Disease*
  • Professional Role
  • Survival Rate


  • Dental Implants