A genetical model for vitiligo

Am J Hum Genet. 1988 Aug;43(2):119-25.

Abstract

A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Alleles
  • Gene Frequency
  • Genes, Recessive
  • Homozygote
  • Humans
  • Models, Genetic*
  • Probability
  • Vitiligo / genetics*