COVID-19 mRNA vaccines

Qingrui Huang; Jiawei Zeng; Jinghua Yan

doi:10.1016/j.jgg.2021.02.006

COVID-19 mRNA vaccines

J Genet Genomics. 2021 Feb 20;48(2):107-114. doi: 10.1016/j.jgg.2021.02.006. Epub 2021 Mar 15.

Authors

Qingrui Huang¹, Jiawei Zeng², Jinghua Yan³

Affiliations

¹ CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
² CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China.
³ CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: yanjh@im.ac.cn.

Abstract

The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Binding Sites / genetics
Binding Sites / immunology
COVID-19 / epidemiology
COVID-19 / immunology*
COVID-19 / virology
COVID-19 Vaccines / genetics
COVID-19 Vaccines / immunology*
COVID-19 Vaccines / therapeutic use
Drug Development
Humans
Pandemics / prevention & control
RNA, Messenger / genetics
RNA, Messenger / immunology*
RNA, Messenger / metabolism
SARS-CoV-2 / immunology*
SARS-CoV-2 / metabolism
SARS-CoV-2 / physiology
Vaccines, Synthetic / genetics
Vaccines, Synthetic / immunology*
Viral Proteins / genetics
Viral Proteins / immunology
Viral Proteins / metabolism
mRNA Vaccines

Substances

COVID-19 Vaccines
RNA, Messenger
Vaccines, Synthetic
Viral Proteins