Suramin keratopathy

Am J Ophthalmol. 1988 Aug 15;106(2):216-20. doi: 10.1016/0002-9394(88)90838-0.


Vortex keratopathy occurred in six patients given high-dose intravenous suramin for adrenocortical carcinoma. The corneal findings were bilateral and symmetric. Two patients complained of foreign-body sensation. One patient developed opacities of the anterior lens epithelium. Histopathologic studies of the eyes in one patient showed intraepithelial apical deposits in the cornea, conjunctiva, and lens epithelia. By electron microscopy, these deposits were found to be membranous lamellar inclusion bodies. These findings, as demonstrated by osmium-PAS staining and electron microscopy, were similar to those in other drug-induced lipid storage diseases.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex
  • Adrenal Gland Neoplasms / drug therapy
  • Adult
  • Carcinoma / drug therapy
  • Corneal Diseases / chemically induced*
  • Corneal Diseases / pathology
  • Corneal Diseases / physiopathology
  • Female
  • Humans
  • Injections, Intravenous
  • Light / adverse effects
  • Male
  • Pain
  • Suramin / adverse effects*
  • Suramin / therapeutic use
  • Visual Acuity


  • Suramin