Detection of Cutibacterium acnes in granulomas of patients with either hypersensitivity pneumonitis or vasculitis reveals that its presence is not unique for sarcoidosis

Els Beijer; Kees Seldenrijk; Bob Meek; Jan Damen; Marian J R Quanjel; Jan C Grutters; Marcel Veltkamp

doi:10.1183/23120541.00930-2020

Detection of Cutibacterium acnes in granulomas of patients with either hypersensitivity pneumonitis or vasculitis reveals that its presence is not unique for sarcoidosis

ERJ Open Res. 2021 May 4;7(2):00930-2020. doi: 10.1183/23120541.00930-2020. eCollection 2021 Apr.

Authors

Els Beijer¹, Kees Seldenrijk², Bob Meek³, Jan Damen⁴, Marian J R Quanjel¹, Jan C Grutters^{1

5}, Marcel Veltkamp^{1

5}

Affiliations

¹ Interstitial Lung Diseases Centre of Excellence, Dept of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.
² Pathology DNA, Dept of Pathology, St Antonius Hospital, Nieuwegein, The Netherlands.
³ Dept of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands.
⁴ Pathology DNA, Dept of Pathology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
⁵ Division of Heart and Lungs, University Medical Centre, Utrecht, The Netherlands.

Abstract

Presence of C. acnes in granulomas is not unique to sarcoidosis but can also be found in patients with HP or EGPA. C. acnes may be involved in the pathogenesis of those granulomatous diseases in a mitogenic way. https://bit.ly/3pU0PeC.