Circumventing Mutation to Nix Neutropenia

N Engl J Med. 2021 May 20;384(20):1956-1958. doi: 10.1056/NEJMcibr2102952.
No abstract available

MeSH terms

  • Animals
  • CRISPR-Cas Systems
  • Disease Models, Animal
  • Gain of Function Mutation
  • Gene Editing*
  • Hematopoietic Stem Cells
  • Humans
  • Leukocyte Elastase / genetics*
  • Mice
  • Mutation*
  • Neutropenia / congenital
  • Neutropenia / genetics
  • Neutropenia / therapy*

Substances

  • Leukocyte Elastase