Principles and open questions in functional brain network reconstruction

Hum Brain Mapp. 2021 Aug 1;42(11):3680-3711. doi: 10.1002/hbm.25462. Epub 2021 May 20.


Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network representation involves often covert theoretical assumptions and methodological choices which affect the way networks are reconstructed from experimental data, and ultimately the resulting network properties and their interpretation. Here, we review some fundamental conceptual underpinnings and technical issues associated with brain network reconstruction, and discuss how their mutual influence concurs in clarifying the organization of brain function.

Keywords: brain dynamics; brain topology; edges; functional imaging; functional networks; nodes; resting state; structure-function relationship; temporal networks.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / physiology*
  • Functional Neuroimaging / methods*
  • Humans
  • Nerve Net / diagnostic imaging*
  • Nerve Net / physiology*