Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

J Clin Res Pediatr Endocrinol. 2021 May 20. doi: 10.4274/jcrpe.galenos.2021.2020.0169. Online ahead of print.


Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency (VDD), often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of VDD in LNH in Turkey and to describe the characteristics of affected newborns.

Methods: Conducted in a cross-sectional design with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered to the FAVOR Web Registry System. Serum samples of the newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathormone (iPTH) and 25 hydroxyvitamin D 25(OH) D levels.

Results: The median onset time of hypocalcemia was 5.0 (range, 4.0-8.0) days of age, with a male preponderance (60.4%). The median serum 25(OH)D levels of the neonates and their mothers were 6.3 (range, 4.1-9.05) ng/ml and 5.2 (range, 4.7-8.8) ng/ml, respectively. The prevalence of VDD (<12 ng/ml) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients.

Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.

Keywords: vitamin D deficiency; hypocalcemia; infant; newborn.