En face optical coherence tomography patterns in patients with angiographically documented uveitic macular edema: a cross-sectional retrospective study

Int Ophthalmol. 2021 Oct;41(10):3303-3312. doi: 10.1007/s10792-021-01892-0. Epub 2021 May 20.


Purpose: To elucidate the en face optical coherence tomography (OCT) patterns of macular edema in eyes with angiographically documented uveitic macular edema (UME) and compare visual acuity (VA), OCT and OCT-angiography (OCT-A) parameters among the morphological subgroups.

Methods: Thirty-nine eyes of 29 patients with angiographically proven UME were enrolled into the study. All patients underwent comprehensive ophthalmological examination including structural OCT and OCT-A in addition to fluorescein angiography. Eyes with UME were divided into three subgroups (petaloid, sunflower and spoke-wheel pattern) with the help of en face OCT imaging.

Results: Posterior uveitis was the most common type of uveitis (17 patients; 58.7%), followed by panuveitis (11 patients; 37.9%) and then intermediate uveitis (1 patient; 3.4%). Underlying causes of uveitis were Behçet's disease (13 patients; 44.8%), idiopathic (11 patients; 37.9%), rheumatoid arthritis (2 patients; 6.9%), sarcoidosis (1 patient; 3.4%), inflammatory polyarthritis (1 patient; 3.4%) and psoriatic arthritis (1 patient; 3.4%). The most common en face OCT pattern was petaloid type (25 of 39 eyes; 64.1%). Eleven eyes (28.2%) had sunflower pattern and three (7.7%) spoke-wheel pattern. There were no statistically significant difference among the subgroups regarding the age, VA, central macular thickness and vessel density.

Conclusion: This study reveals three morphological en face OCT patterns in eyes with UME and en face OCT may find a niche in the UME classification with the accumulation of experience among the uveitis experts.

Keywords: En face optical coherence tomography imaging; Fluorescein angiography; Macula; Macular edema; Uveitis.

MeSH terms

  • Behcet Syndrome*
  • Cross-Sectional Studies
  • Fluorescein Angiography
  • Humans
  • Macular Edema* / diagnosis
  • Macular Edema* / etiology
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Uveitis* / complications
  • Uveitis* / diagnosis