Expression of gilt acts as a positive regulator of mouse hematopoietic progenitor cells

Blood Cells Mol Dis. 2021 Sep:90:102574. doi: 10.1016/j.bcmd.2021.102574. Epub 2021 Apr 30.

Abstract

Gamma interferon inducible lysosomal thiol reductase (GILT), is known to be involved in immunity, but its role in hematopoiesis has not been previously reported. Herein, we demonstrate using gilt knockout (-/-) mice that loss of gilt associates with decreased numbers and cycling status of femoral hematopoietic progenitor cells (CFU-GM, BFU-E, and CFU-GEMM) with more modest effects on splenic progenitor cells. Thus, GILT is associated with positive regulation of hematopoietic progenitor cells in mice, mainly in bone marrow.

Keywords: BFU-E; Bone marrow; CFU-GEMM; CFU-GM; Gilt; Hematopoietic progenitor cells; Spleen.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Gene Expression Regulation, Enzymologic*
  • Hematopoietic Stem Cells / enzymology*
  • Mice
  • Mice, Knockout
  • Oxidoreductases Acting on Sulfur Group Donors / biosynthesis*
  • Oxidoreductases Acting on Sulfur Group Donors / genetics

Substances

  • Ifi30 protein, mouse
  • Oxidoreductases Acting on Sulfur Group Donors