GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

Circ Res. 2021 Jul 23;129(3):383-396. doi: 10.1161/CIRCRESAHA.120.318629. Epub 2021 May 21.

Abstract

[Figure: see text].

Keywords: caspase; cell death; inflammation; necrosis; pyroptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Caspases, Initiator / metabolism
  • Cell Hypoxia
  • Cells, Cultured
  • Humans
  • Interleukin-18 / metabolism
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Myocardial Reperfusion Injury / metabolism*
  • Myocytes, Cardiac / metabolism*
  • Myosin Heavy Chains / genetics
  • Myosin Heavy Chains / metabolism
  • Phosphate-Binding Proteins / metabolism*
  • Pyroptosis*
  • ST Elevation Myocardial Infarction / metabolism*

Substances

  • Gsdmd protein, mouse
  • Interleukin-18
  • Intracellular Signaling Peptides and Proteins
  • Myh6 protein, mouse
  • Phosphate-Binding Proteins
  • Casp4 protein, mouse
  • Caspases, Initiator
  • Myosin Heavy Chains