GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

Huairui Shi; Yang Gao; Zhen Dong; Ji'e Yang; Rifeng Gao; Xiao Li; Shuqi Zhang; Leilei Ma; Xiaolei Sun; Zeng Wang; Feng Zhang; Kai Hu; Aijun Sun; Junbo Ge

doi:10.1161/CIRCRESAHA.120.318629

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

Circ Res. 2021 Jul 23;129(3):383-396. doi: 10.1161/CIRCRESAHA.120.318629. Epub 2021 May 21.

Authors

Huairui Shi^{1

2

3}, Yang Gao^{1

2

3}, Zhen Dong^{1

3}, Ji'e Yang^{1

2

3}, Rifeng Gao⁴, Xiao Li^{1

2

3}, Shuqi Zhang^{1

2

3}, Leilei Ma^{1

2

3}, Xiaolei Sun⁵, Zeng Wang⁵, Feng Zhang^{1

2

3}, Kai Hu^{1

2

3}, Aijun Sun^{1

5

2

3}, Junbo Ge^{1

5

2

3}

Affiliations

¹ Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (H.S., Y.G., Z.D., J.Y., X.L., S.Z., L.M., F.Z., K.H., A.S., J.G.).
² NHC Key Laboratory of Viral Heart Diseases, Shanghai, China (H.S., Y.G., Z.D., J.Y., X.L., S.Z., L.M., F.Z., K.H., A.S., J.G.).
³ Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, China (H.S., Y.G., Z.D., J.Y., X.L., S.Z., L.M., F.Z., K.H., A.S., J.G.).
⁴ Shanghai Fifth Peoples Hospital, Fudan University, Shanghai, China (R.G.).
⁵ Institute of Biomedical Science, Fudan University, Shanghai, China (X.S., Z.W., A.S., J.G.).

Abstract

[Figure: see text].

Keywords: caspase; cell death; inflammation; necrosis; pyroptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Animals
Caspases, Initiator / metabolism
Cell Hypoxia
Cells, Cultured
Humans
Interleukin-18 / metabolism
Intracellular Signaling Peptides and Proteins / metabolism*
Male
Mice
Mice, Inbred C57BL
Middle Aged
Myocardial Reperfusion Injury / metabolism*
Myocytes, Cardiac / metabolism*
Myosin Heavy Chains / genetics
Myosin Heavy Chains / metabolism
Phosphate-Binding Proteins / metabolism*
Pyroptosis*
ST Elevation Myocardial Infarction / metabolism*

Substances

Gsdmd protein, mouse
Interleukin-18
Intracellular Signaling Peptides and Proteins
Myh6 protein, mouse
Phosphate-Binding Proteins
Casp4 protein, mouse
Caspases, Initiator
Myosin Heavy Chains