Candidemia and Invasive Candidiasis

Infect Dis Clin North Am. 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007.


Invasive candidiasis (IC) is a collective term that refers to a group of infectious syndromes caused by a variety of species of Candida, 6 of which cause most cases globally. Candidemia is probably the most commonly recognized syndrome associated with IC; however, Candida can cause invasive infection of any organ, especially visceral organs, vasculature, bones and joints, the eyes and central nervous system. Targeted prevention and empirical therapy are important interventions for patients at high risk for IC, and the current approach should be based on a combination of clinical risk factors and non-culture-based diagnostics, when available.

Keywords: Antifungals; Bloodstream infection; Candida; Fungal infection; Invasive candidiasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Candida / isolation & purification
  • Candida / pathogenicity*
  • Candidemia* / diagnosis
  • Candidemia* / drug therapy
  • Candidemia* / epidemiology
  • Candidiasis
  • Candidiasis, Invasive* / diagnosis
  • Candidiasis, Invasive* / drug therapy
  • Candidiasis, Invasive* / epidemiology
  • Humans
  • Mycoses
  • Sepsis


  • Antifungal Agents

Supplementary concepts

  • Systemic candidiasis