Ketamine for a Boost of Neural Plasticity: How, but Also When?

doi:10.1016/j.biopsych.2021.03.014

Comment

. 2021 Jun 1;89(11):1030-1032.

doi: 10.1016/j.biopsych.2021.03.014.

Ketamine for a Boost of Neural Plasticity: How, but Also When?

Hao Wu¹, Neil K Savalia², Alex C Kwan³

Affiliations

¹ Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut.
² Medical Scientist Training Program, Yale University School of Medicine, New Haven, Connecticut.
³ Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut. Electronic address: alex.kwan@yale.edu.

PMID: 34016377
PMCID: PMC8190578
DOI: 10.1016/j.biopsych.2021.03.014

Comment

Ketamine for a Boost of Neural Plasticity: How, but Also When?

Hao Wu et al. Biol Psychiatry. 2021.

. 2021 Jun 1;89(11):1030-1032.

doi: 10.1016/j.biopsych.2021.03.014.

Authors

Hao Wu¹, Neil K Savalia², Alex C Kwan³

Affiliations

¹ Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut.
² Medical Scientist Training Program, Yale University School of Medicine, New Haven, Connecticut.
³ Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut. Electronic address: alex.kwan@yale.edu.

PMID: 34016377
PMCID: PMC8190578
DOI: 10.1016/j.biopsych.2021.03.014

No abstract available

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Figures

**Figure 1.. A schematic of the reported time courses of ketamine’s neural and behavioral effects in mice and humans.**
The circles denote the response, normalized by subtracting effects of ketamine from vehicle or placebo, at specific time points as reported in the current and previous studies.

See this image and copyright information in PMC

Comment on

Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms.
Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Kozorovitskiy Y. Wu M, et al. Biol Psychiatry. 2021 Jun 1;89(11):1096-1105. doi: 10.1016/j.biopsych.2020.12.022. Epub 2021 Jan 8. Biol Psychiatry. 2021. PMID: 33637303 Free PMC article.

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References

1. Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. (2010): mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 329:959–964. - PMC - PubMed
1. Phoumthipphavong V, Barthas F, Hassett S, Kwan AC (2016): Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex. eNeuro. 3:ENEURO.0133-0115.2016. - PMC - PubMed
1. Moda-Sava RN, Murdock MH, Parekh PK, Fetcho RN, Huang BS, Huynh TN, et al. (2019): Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 364. - PMC - PubMed
1. Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Kozorovitskiy Y (2021): Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms. Biological Psychiatry. in press. - PMC - PubMed
1. Kwon HB, Sabatini BL (2011): Glutamate induces de novo growth of functional spines in developing cortex. Nature. 474:100–104. - PMC - PubMed

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[1] Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. (2010): mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 329:959–964. - PMC - PubMed

[2] Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, et al. (2010): mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 329:959–964. - PMC - PubMed

[3] Phoumthipphavong V, Barthas F, Hassett S, Kwan AC (2016): Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex. eNeuro. 3:ENEURO.0133-0115.2016. - PMC - PubMed

[4] Phoumthipphavong V, Barthas F, Hassett S, Kwan AC (2016): Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex. eNeuro. 3:ENEURO.0133-0115.2016. - PMC - PubMed

[5] Moda-Sava RN, Murdock MH, Parekh PK, Fetcho RN, Huang BS, Huynh TN, et al. (2019): Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 364. - PMC - PubMed

[6] Moda-Sava RN, Murdock MH, Parekh PK, Fetcho RN, Huang BS, Huynh TN, et al. (2019): Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 364. - PMC - PubMed

[7] Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Kozorovitskiy Y (2021): Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms. Biological Psychiatry. in press. - PMC - PubMed

[8] Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Kozorovitskiy Y (2021): Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms. Biological Psychiatry. in press. - PMC - PubMed

[9] Kwon HB, Sabatini BL (2011): Glutamate induces de novo growth of functional spines in developing cortex. Nature. 474:100–104. - PMC - PubMed

[10] Kwon HB, Sabatini BL (2011): Glutamate induces de novo growth of functional spines in developing cortex. Nature. 474:100–104. - PMC - PubMed

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Ketamine for a Boost of Neural Plasticity: How, but Also When?

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