Low-cost CRISPR diagnostics for resource-limited settings

Trends Genet. 2021 Sep;37(9):776-779. doi: 10.1016/j.tig.2021.05.001. Epub 2021 May 17.


Next-generation sequencing (NGS) has identified disease hallmarks and catalogued a vast reservoir of genetic information from humans and other species. Precise nucleotide-interrogation properties of clustered regularly interspaced short palindromic repeats (CRISPR) proteins have been harnessed to rapidly identify DNA-RNA signatures for diverse applications, bypassing the cost and turnaround times associated with diagnostic NGS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • CRISPR-Associated Proteins / genetics
  • Clustered Regularly Interspaced Short Palindromic Repeats*
  • DNA
  • Genetic Techniques* / economics
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Plants, Medicinal / genetics
  • RNA
  • Tuberculosis / diagnosis
  • Tuberculosis / microbiology


  • Biomarkers, Tumor
  • CRISPR-Associated Proteins
  • RNA
  • DNA