Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice

Rufeng Lu; Yueguo Wu; Honggang Guo; Zhuoyi Zhang; Yuzhou He

doi:10.1177/15593258211011335

Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice

Dose Response. 2021 Apr 29;19(2):15593258211011335. doi: 10.1177/15593258211011335. eCollection 2021 Apr-Jun.

Authors

Rufeng Lu¹, Yueguo Wu², Honggang Guo³, Zhuoyi Zhang¹, Yuzhou He¹

Affiliations

¹ Department of Emergency, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
² Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
³ Key Laboratory of Experimental Animal and Safety Evaluation, Hangzhou Medical College, Hangzhou, China.

Abstract

Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.

Keywords: Toll-like receptor 4; acute lung injury; inflammatory cytokines; influenza A virus; salidroside.