Objective: To investigate the expression of metastasis-associated lung adenocarcinoma transcript 1 (Malat-1) in bladder carcinoma and its relationship with clinicopathological characteristics and prognosis.
Methods: Specimens were collected from 90 patients with bladder carcinoma who underwent urological surgery in our hospital. Twenty patients diagnosed with benign prostatic hyperplasia were selected as the negative control. The expression of Malat-1 was detected by real-time reverse transcription PCR, and its relationship with clinicopathological factors and prognosis was analyzed.
Results: The expression of Malat-1 in bladder carcinoma tissues (2.55±0.31) was higher than that in adjacent tissues (1.62±0.42) and normal bladder mucosa tissues (0.84±0.06); the differences were statistically significant (t=13.647 and 27.302, both P<0.001). The high expression rate of Malat-1 in bladder carcinoma tissues (86.67%) was significantly higher than that in adjacent tissues (22.22%) and normal bladder mucosa tissues (5.00%; P=0.000 and 0.000). The high expression rate of Malat-1 was correlated with age, tumor staging, degree of differentiation and lymph node metastasis (P=0.018, 0.000, 0.000, and 0.000). The median survival time and the 1-year, 3-year and 5-year survival rates of patients with high Malat-1 expression were lower than those with low expression of Malat-1 (P=0.006, 0.011, 0.000 and 0.002). High expression of Malat-1 is an independent risk factor for poor overall survival (OS) in bladder cancer patients.
Conclusion: Overexpression of Malat-1 in bladder carcinoma tissues is associated with malignant biological characteristics and poor prognosis of patients.
Keywords: Metastasis-associated lung adenocarcinoma transcript 1; bladder carcinoma; invasion; prognosis.
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