Effect of gamma globulin combined with creatine phosphate on viral myocarditis

Jing-Hui Li; Ting-Ting Li; Xing-Sen Wu; Ding-Lin Zeng

Effect of gamma globulin combined with creatine phosphate on viral myocarditis

Am J Transl Res. 2021 Apr 15;13(4):3682-3688. eCollection 2021.

Authors

Jing-Hui Li¹, Ting-Ting Li², Xing-Sen Wu¹, Ding-Lin Zeng¹

Affiliations

¹ Zhangzhou Zhengxing Hospital Zhangzhou, China.
² The Third Hospital of Zhangzhou Zhangzhou, China.

PMID: 34017551
PMCID: PMC8129424

Abstract

Objective: This study aimed to investigate the effect of gamma globulin (IVIG) and creatine phosphate (CP) on viral myocarditis (VMC).

Methods: We enrolled 121 young patients with VMC who were admitted in our hospital from February 2017 to September 2018, and divided them into two groups as follows: study group (62 patients, IVIG + CP + routine treatment), and control group (59 patients, conventional treatment). Patient's baseline data, including gender, age, disease course, etiology, cardiac function classification, and severity, were collected. Ejection fraction (EF), fractional shortening (FS), and mitral ratio of peak early to late diastolic filling velocity (E/A ratio) before and after treatment were recorded. These changes include the lactate dehydrogenase, creatine kinase (CK), aspartate aminotransferase, creatine kinase isoenzyme (CK-MB), and cardiac troponin I (CTnI). Furthermore, the changes in immune factors such as CD3⁺, CD4⁺, and CD8⁺ before and after the treatment were determined.

Results: The study group had a significantly higher response rate than the control group (P < 0.05). After treatment, the ejection fraction, fractional shortening, and mitral ratio of peak early-to-late diastolic filling velocity were more significantly improved in the study group than in the control group (P < 0.05). The electrocardiogram (ECG) results of the study group were also significantly better than those of the control group (P < 0.05). The levels of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), creatine kinase isoenzyme (CK-MB), and cardiac troponin I (CTnI) in the study group were all significantly better than those in the control group (P < 0.05). Symptom recuperation, cardiac function recovery, and ECG and myocardial enzyme normalization were significantly faster in the study group than those in the control group (P < 0.05). The immune factor levels in the study group also significantly improved compared with those before the treatment (P < 0.05). Meanwhile, the adverse reactions in both groups showed no differences (P < 0.05).

Conclusion: IVIG combined with CP exhibited better clinical effects and effectively boosted the immune system of patients with VMC.

Keywords: Viral myocarditis; creatine phosphate; gamma globulin.