GLUT1 biological function and inhibition: research advances

Future Med Chem. 2021 Jul;13(14):1227-1243. doi: 10.4155/fmc-2021-0071. Epub 2021 May 21.


The GLUT is a key regulator of glucose metabolism and is widely expressed on the surface of most cells of the body. GLUT provides a variety of nutrients for the growth, proliferation and differentiation of cells. In recent years, the development of drugs affecting the energy intake of tumor cells has become a research hotspot. GLUT inhibitors are gaining increased attention because they can block the energy supply of malignant tumors. Herein, we elaborate on the structure and function of GLUT1, the structural and functional differences among GLUT1-4 transporters and the relationship between GLUT1 and tumor development, as well as GLUT1 transporter inhibitors, to provide a reference for the development of new GLUT1 inhibitors.

Keywords: GLUT1; HCC; cancer; inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anilides / chemistry
  • Anilides / metabolism
  • Anilides / therapeutic use
  • Biological Products / chemistry
  • Biological Products / metabolism
  • Biological Products / therapeutic use
  • Glucose / metabolism
  • Glucose Transporter Type 1 / antagonists & inhibitors
  • Glucose Transporter Type 1 / metabolism*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Protein Isoforms / antagonists & inhibitors
  • Protein Isoforms / metabolism


  • Anilides
  • Biological Products
  • Glucose Transporter Type 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Protein Isoforms
  • fasentin
  • Glucose